Exploring the Mechanistic interplay between Chronic Inflammation and Gastrointestinal Cancer in the Gut Microbiome: A Review

Authors

• Hanan Mohamed Abd Elmoneim, Department of Pathology, Faculty of Medicine, University of Umm Al-Qura, Makkah, Saudi Arabia;Follow

Keywords

Inflammation, Gastrointestinal cancer, Microbiota.

Document Type

Review Article

Abstract

There are complex and heterogeneous immunological milieus of the gastrointestinal system, so there is a high mortality rate from malignancies affecting the gastrointestinal system. The pathophysiology of cancer has long been thought to be significantly influenced by inflammation. However, several of the mechanisms underlying its tumor-promoting activities have only lately been discovered. Both beneficial and harmful microorganisms play a crucial role in controlling the host immune system and, eventually, inflammation. Furthermore, bacteria may also influence how a tumor develops through different mechanisms, including long-term inflammation activation, changes to the tumor microenvironment, and genotoxic response induction. A significant percentage of cancers are caused by microbial species; according to conservative estimates, infectious pathogens are responsible for at least 15% of all cancer cases. The role of the gastrointestinal microbiota in the emergence of cancer is not well understood. This review will include a broad overview of commensal microbiota, inflammation, cancer, and the role of bacteria in these developing fields.

Recommended Citation

Abd Elmoneim, Hanan Mohamed (2025) "Exploring the Mechanistic interplay between Chronic Inflammation and Gastrointestinal Cancer in the Gut Microbiome: A Review," Saudi Toxicology Journal: Vol. 2: Iss. 2, Article 3.
DOI: https://doi.org/10.70957/uqu.edu.sa/s.toxicology.s/stj.2025.2.3
Available at: https://stj.researchcommons.org/journal/vol2/iss2/3

DOI

https://doi.org/10.70957/uqu.edu.sa/s.toxicology.s/stj.2025.2.3